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KMID : 0370019960100000187
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Chung-Ang Journal of Pharmacal Sciences
1996 Volume.10 No. 0 p.187 ~ p.194
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Syntheses of Benzothiazolyl Biguanides
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Abstract
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In order to find new antimicrobial agents, twelve new alkylene bis benzothiazolyl biguanides and eight benzothiazoly biguanides were synthesized. The treatment of alkylenediamines·2HCI with sodium dicyanamide afforded alkylene bis cyanoguanidines. Alkylene bis benzothiazolyl biguanides were synthesized by the reaction of alkylene bis cyanoguanidines with 2-aminobenzothiazole. Benzothiazolyl biguanides were obtained from N-cyanoheterocyclylamidines and 2-aminobenzothiazoles through the similar procedures.
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